Vaspin promotes insulin sensitivity in elderly muscle and is upregulated in obesity

Circulating vaspin is unrelated to insulin sensitivity in a cohort of non-diabetic humans Short running title: serum vaspin and insulin sensitivity

Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans.

OBJECTIVE To study the association of vaspin with glucose metabolism. DESIGN Cross-sectional and intervention study. SUBJECTS AND METHODS The association of serum vaspin with metabolic and anthropometric characteristics was investigated in 108 volunteers. Euglycemic-hyperinsulinemic clamps (EHC) were performed in 83 of the participants. Changes of circulating vaspin levels were additionally...

The Effect of Acute Exercise on Serum Vaspin Level and Its Relation to Insulin Sensitivity in Overweight Elderly Men

Article history: Received: 29 Jan 2013 Accepted: 27 Feb 2013 Available online: 24 Apr 2013 ZJRMS 2014 Aug; 16(8): 16-19 Background: Vaspin is a new discovered adipocytokine which is a member of serine protease inhibitor family secreted from adipose tissue and might play a role in insulin sensitivity. The purpose of this study was to investigate the effect of acute exercise on serum vaspin level...

Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

OBJECTIVE Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-receptor gamma (PPARγ). METHODS To assess the specific role of SIRT1 in adipocytes, we generated Si...

Serum Adiponectin and Vaspin levels in Abdominal Obesity and Type 2 Diabetes Mellitus

Abstract Objective: Adiponectin and vaspin are adipocyte-derived proteins and involved in the regulation of glucose metabolism and obesity related disorders. The mechanisms that adipokines might be linked to disturbance of glucose are unclear. Thus, this study investigated the levels of serum adiponectin and vaspin, blood lipid profiles, and abdominal obesity in type 2 diabetes (T2DM) patients...